Thank you for your response Terri. My husband has been off all antibiotics for nearly 1 month now. He has gained 3 pounds and he is eating very well. He is still lacking energy and sleeping about 14 hours out of a 24 hour day. The doctors are saying that is due to the infections (Mac and pseudomonous). However, the pseudomonous must be lurking in the background for now because he has not had a flair up since the end of July. The ID doctor wants to begin the Big 3 again but we want to hold off for at least 2 months so that my husband can get stronger. The ID doctor is indicating that he will give him 1/2 the dosage and only 5 days per week. Do you ever wonder if the ID doctors get some sort of kick back from the pharmaceutical companies for getting their patients to purchase the big 3 antibiotics?