I actually lost the weight I had gained on tamoxifen. Then I had an accident and gained it back, now I am working on getting off again. I put drawstrings in all of my skirts because over the last 17 years I gained and lost hundreds of pounds from treatments. For me the reality of knowing this thing would have killed me 17 years ago or somewhere in between without all these advances is a scary thing. I would have missed sooooo much.