@suzie2017 Suzie, I am sorry to hear that your husband is having such a rough time. I know it is hard on you too. The pseudomonas can be treated not using any of the BIG 3. In fact, I don't think the Big 3 kills pseudomonas. One single antibiotic can treat that. I did nebulized tobramycin to get rid of it. I felt better in 30 days. I still nebulize the tobramycin every other month to keep it away. Someone else on this site took another single antibiotic and got rid of it as well. I will poke around and see who posted that and what they took. My Mayo clinic dr put me on a single, but alternating antibiotics for life. I have had only one infection since 2013, and that was pseudomonas. I got over that in one month on the tobramycin. It sounds like your husband needs to be on continuous monthly antibiotics indefinitely. (Not one of the BIG 3) His lungs are sick and damaged and therefore will always be prone to infections. Perhaps you can discuss that with his doctor. Note: when I do alternating antibiotics in pill form; it is only for 10 days a month. Thank you for the update on your dear husband. I hope he is feeling better before long.