Hi Cathy, I took Cymbalta for about a year (+). My doctor told me to take at night because it causes drowsiness. It ended up being the opposite for me, which he then said does happen with a small percentage of people. So I switched to taking it in the morning. I felt like it did take the edge off the pain but at the time had no idea I had SFN and decided to go off Cymbalta. Overall I just didn’t like how it made me feel (can’t really pin it down to something specific but maybe just that I felt emotionally/mentally numb). To answer your question about RLS, I never put two and two together but in hindsight I did have RLS more so then. Fast forward, I have been diagnosed with SFN/AN and my neurologist has prescribed Amitriptyline. We talked about many other options (lyrica, gabapentin, etc) but I’m pretty sensitive to drugs, so we decided to give amitriptyline a try. I started on a low dose and am gradually working my way up. With each increase, I notice slight improvements.

I hope you find something that works well for you. Take care.