I have been on and off prednisone or Medrol for over 40 years, I have chronic sarcoidosis. I have had 3 lower back surgeries which I don't know were associated with and numerous bouts of different conditions, all treated with some type of prednisone. Over the years I don't believe I had pain from the prednisone. I am now 78 and have a lot of pain from lower back, bone joints and neuropathy in one foot and calf.