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@lindes

Well, a step into the neuro direction is the use of Gabapentin. Actually similar approaches are used with the spinal nerve simulators, and even TENS products.

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Replies to "Well, a step into the neuro direction is the use of Gabapentin. Actually similar approaches are..."

Maybe but this 2009 study points out that that gabapentin halts the formation of new synapses, possibly explaining its therapeutic value in mitigating epileptic seizures and chronic pain. -- Study pinpoints key mechanism in brain development, raising questions about use of antiseizure drug: https://med.stanford.edu/news/all-news/2009/10/study-pinpoints-key-mechanism-in-brain-development-raising-questions-about-use-of-antiseizure-drug.html

This is what I've read about how neuroplasticity works...just one article but there are a lot more on the topic.
"Neuroplastic therapy for chronic pain is focused on retraining the (unconscious) brain to learn that it is not helpful to experience chronic pain. Thus, successfully retraining the brain in this way diminishes or eliminates chronic pain."
-- Chronic Pain Therapy Grounded in Neuroplasticity: https://hansmalab.physics.ucsb.edu/index.php/chronic-pain-therapy-grounded-in-neuroplasticity/