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Starting MAC treatment with "big three" drugs: What to expect?

MAC & Bronchiectasis | Last Active: May 8 5:56pm | Replies (192)
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@shur61

I am on the second month of “The Big Three” so far except for a little stomach issue I am doing great I take the Azithromycin and the Ethambutol as soon as I wake up then eat at least an hour later, then I take the Rifampin before bed at least 2 hours after eating, I take 1-2 probiotics a day when I remember and a multivitamin at lunch

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extracare808 | @extracare808 | Oct 28, 2021

^ This. Dr Huitt from NJH recommends this very regimen. She said it makes it easy to tease out the root cause of side effects. There's a great NJH video of Dr Huitt discussing the meds and management of side effects.

I've been on the Big 3 for going on 2 months now and have only had intermittent stomach pain within the first couple of hours of taking my morning dose of the A&E. Was preparing for horrific side effects from the Rifampin, but, thus far, have had none (knock on wood).

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