All my life and I'm a 70 year old female. I've always been active and I exercise 6 days a week, still. The only thing that ever worked for me was, originally, Bisacodyl. BUT it leaves me weak and shaky. But it did clean me out. NOW what is working for me, although it took a week or so for my body to adjust, is Prunlax, over the counter. It's much easier on my body, I feel so much better! I just discovered that it is made in an extra strength, which I will try next. I have a tortuous intestine. I had another colonoscopy in 2020 and I'm not doing it again. It left me in a lot of discomfort for weeks and I understand I run the risk of perforating the intestine trying to get the scope through me. There are other ways to look for polyps, if necessary. But I made the decision to stop the colonoscopies. I learned of Prunelax through someone on this site. It has worked for her son, who had issues for 20 years! Well, like I said, I'm 70 and I've been dealing with constipation and all it's repercussions for years. It's worth a try. I've used Miralax, stool softeners, and everything else the doctors told me to do,.....drink more fluids, eat a good vegetable/fiber diet, take magnesium, and so on. The Prunelax performed the best in my experience. Everyone is different so it's a process finding out what works for your body. I wish you patience and the very best.