I have been on xeloda for three years. After I take my pills, I first soak my feet in cold water for 15 minutes, then use the urea cream and sit with my feet on a foot rest. I drink lots (50-70 oz.) of water after each dose of xeloda. I wear cotton socks to keep my feet cool indoors, and Adidas when I go out. I ride a bike whenever possible. I take 4 mg zofran tabs three times a day for nausea. Hope this helps. It is a challenging treatment.