I'm at 1200 gaba twice a day and a 325 Lyrica at night. We need to raise the gaba or add something else as I'm in pain most of every day, I get a few hours relief when I focus on something else. We started with one 300 gaba each day, it worked for awhile, then 3 of those, then my doctor referred me to a neurologist who did testing and official diagnosis. Gradually, she raised it as my condition progressed, then referred me to a pain specialist who has gradually raised it to present levels,I hope that helps. I don't remember exactly how much when. I hope that helps ... Peggy