Just a quick note, I don't believe it's a matter of if they have ever heard of this substance. I did run all of the original supplements in the current 525 product when we were ordering them separately. It was over 20 pills daily for all of the supplements and vitamins we were taking in the Facebook group. Because it was difficult for a lot of members to take so many pills, the person who started the group, Bob Diamond, worked with a local pharmaceutical company to see if we could combine some of the vitamins into a smaller number of pills. Hence the name 525 (5 capsules in the morning, 2 at noon, 5 in the evening vs the 20+ pills). The cost is close to the same amount we were paying through Amazon to purchase the individual items, about $6.50/day. Another benefit is that the different items were ordered when you ran out and they typically ran out at different times during the month due to how many pills were in each product.

All of the products have scientific evidence of benefiting/helping nerve regeneration and health. I ran the original list of supplements by my Mayo doctor who sent them to a pharmacist for their thoughts and she didn't have an issue with them. Most of the ingredients are listed on the Foundation for Peripheral Neuropathy here: https://29fvx519grkh3bdqrc16zioc-wpengine.netdna-ssl.com/wp-content/uploads/2016/10/Supplements-Not-highlighted.pdf. Here's another article that lists a lot of the same supplements - https://www.healthline.com/health/neuropathy-supplements

I started taking the Protocol 525 in Sept 2016 before it became the Protocol 525 and we ordered everything through Amazon and sometimes the manufacturer's website if the price was better. I only have the numbness and do feel that it has slowed or possibly stopped the progression of my idiopathic small fiber PN as the numbness was close to the knees in both legs when I started and within a few months of taking the supplements it seemed to be just above my ankles. Since I had tried so many different things with very little help, this was a big deal for me. I realize that this is a little subjective on my part and it may not work for everyone but if you've tried everything else it may be worthwhile to try. I would certainly run it by my doctor first just to make sure there are no interactions with any other medications you may be taking.

The ingredients for the Protocol 525 are listed under the frequently asked questions on their site here: https://theprotocol525.com/faq/. Good luck whatever you decide. I hope you find something that helps!