My husband was prescribed Seroquel to help him sleep but the benefits went far beyond that, much to our delight. They reduced his tremors and increased his gait stability for a time. When he passed away he was close to the highest dose they could prescribe. Frequently doctors in nursing homes would decide they could not give him Seroquel because of the antipsychotic indication. Robert was not psychotic. He had fronto-temporal dementia. When a doctor would remove the Seroquel he would have extreme discomfort and the tremors would return almost immediately followed by a sharp decline in his mood and sense of safety. I did battle with the nursing home doctors each time and they returned him to the seroquel wit5h great success. Robert did not have heart problems nor did he show any signs of the Seroquel causing any heart problems.
My brother was recently put on Seroquel to help control bi-polar symptoms and it has worked well for him but they had to lower his dose. His blood pressure was increasing and they determined it was related to the Seroquel increase in dosage. He is doing o.k. at the lowered dose but not as well. He does not have lingering heart problems, symptoms, etc.
Seroquel helps so much that the temptation is to turn a blind eye to any negative impacts. In my husband's case the negative impacts would have had to have been dramatic. He was terminal and the difference Seroquel made in his life outweighed any other considerations.
In my brother's case he needed to lower his blood pressure and the change in dosage of Seroquel lowered his blood pressure.
Anecdotally the Seroquel benefits in patients with FTD are outstanding.
I have not seen one post indicating serious heart problems. Increases in blood pressure can be serious but once dosage is lowered the problem seems to take care of itself.