Hi @irolynn
Welcome to Mayo Clinic Connect. You will see that I moved your comment from mental health about Trintellix to your conversation here and I linked this discussion to both groups for you. This way you still can see it in depression and anxiety and mental health, but you can keep up with everyone who responds with just the one conversation.

I would like to introduce you to @elwooodsdad, he started Trintellix and perhaps can share his experience with the medication.

That being said, you should really contact your physician or their nurse who prescribed you the medication. completely stopping one medication and starting a different one without the proper tapering can be very detrimental to your physical and psychological health. I would urge them to speak with you over the phone or make an emergency appointment. Tell them that your side effects from this medication are getting unbearable and it cannot wait a week.

Are they aware of the itching and terrible anxiety?