Hello @hopefulhealing and welcome to Mayo Clinic Connect.

You are an excellent historian with your health history and that is important given the kind of problems you have experienced throughout your lifetime. You do not mention your age but you certainly are dealing with many different problems, some of which you said might be genetic in origin. I'm just wondering if any of your doctors have recommended any genetic testing? If not, this might be something you could ask your doctor about. You mentioned the possibility of having an endoscopic ultrasound (EUS) which sounds like a good idea given many of your symptoms.

Is there any family history of these types of problems? Have you been seen by a rheumatologist who can look for auto-immune disorders?

I would like to invite some other members to this conversation including @astaingegerdm, @becsbuddy and @gingerw. Perhaps they can offer some other suggestions.

@hopefulhealing, what is your most difficult symptom right now?