After the second Moderna dose, I noticed that the joints in the middle fingers became slightly swollen and painful. No problem that occasional acetaminophen can help. Now just yesterday, a day after my Senior Influenza vaccine injection, I experienced joint pain in those fingers and seemingly like all my toe bones. After taking an extended release acetaminophen tablet, he foot pain and most of the finger joint pain gone. Since vaccines activate an immune response in the body, my virologist friend has suggested that it is possible.