I was diagnosed with collagenous colitis 2008. I was treated with Methotrexate and symptoms disappeared. However, it seems like I developed a different kind of intestinal autoimmune illness after a year or so. Budesonide helped some, but not enough. After a few years I tried Imuran, immunosuppressive. It worked, but there were side effects such as severe infections. After 7 months I stopped taking it and I have not had any recurrence. I have other GI problems keeping me busy, but nothing autoimmune.