Hi, Pam..... I was told by Mayo's the tobramycin was the only way to rid the pseudemonas and they asked me to come to Rochester for a trial with it before starting the program. I did that and I did a vial through a nebulizer while someone there was with me -- no problems. So, I was given the prescription for it and was told it would take possibly a year for it to rid the bacteria. I got along with it okay for maybe 2 months and then started having difficulty breathing when I used it and it was very scary to me and I was taken off it. I've never tried it again but perhaps I will one day. I've been off it about 2 years now. I do know two ladies,though who are using it and never have any trouble with it and the results are good. So...... let me know if you give it a try. It's very expensive but my doctor at Mayo's wrote a prescription for me and Medicare picked it up.