I have been taking Cymbalta for many years, maybe 20 years. I have also tried Wellbutrin in the past and it made me too anxious. Recently Cymbalta became less effective so my doc added Wellbutrin to augment Cymbalta. I have now tapered off the Cymbalta and am only taking the Wellbutrin and feel a little more anxiety but also more energy. I am only taking 100mg extended release. Hoping that at this low dose I will not be so anxious as I do like the energy. Seems like I had to drop the Cymbalta to get this effect.