I had two (one in each foot) Morton's neuromas that, over time, resulted in not being able to walk. That made me gain a lot of weight, of course, which made the pain worse. I was finally given duloxetine to replace the antidepressant I was on since it is very good with nerve pain as well as an antidepressant. I never had, in the many years I've taken it, any problems with the duloxetine except memory screw-ups. It is now interfering with the Pramipexole I use for my Restless Leg Syndrome so I am tapering off of the duloxetine. I was very happy with it for years but can't take it anymore.

When I was diagnosed with Morton's neuromas, my podiatrist performed an experimental procedure, snipping a tendon to relieve the pressure on the neuromas. It didn't work. Then he surgically removed them. It didn't work and I ended up with neuropathy in both feet. Ouch. I haven't been able to wear anything but Crocs since the surgeries.