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Kidney disease: Figuring out minimal change disease (MCD)
Kidney & Bladder | Last Active: Oct 16, 2021 | Replies (28)Comment receiving replies
Just an update regarding my Nephrotic Syndrome MCD relapse. My early August urine Pr/Cr was 13.0. After being on 40 days of high dose prednisone, my urine Pr/Cr is almost normal (.276), so I will begin a slow taper… 5mg decrease pred every 2 weeks adding tacrolimus or mycophenolate as a second immunosuppressant when I am taking 20 mg pred daily. I am still trying to decide between the two drugs. I would very much appreciate any input regarding side effects of Prograf and CellCept. My rheumatologist prefers CellCept for lupus nephritis, but literature refers to the direct effect of tacrolimus on kidney podocytes (the actual cells allowing protein loss.)
Thanks to everyone contributing! I learn something with each person’s history.
RKN
Replies to "Just an update regarding my Nephrotic Syndrome MCD relapse. My early August urine Pr/Cr was 13.0...."
I have been off line for a while. I am currently taking Tacrolimus 3mg every 12hr. I tolerate Prograf ok but my issues are the cost of the Prograf ($800 for 30 days). I use GoodRx to shop for generic, but I never know who the manufacturer is. There are several Tacrolimus generic’s that I can’t tolerate. I have severe stomach issues, n/v, chills, kidney pain etc..excessive urinating. Because I don’t get monthly levels I am not sure if my levels are stable. Prograf was helpful with reducing symptoms of Proteinuria but the generics are questionable.
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Hi I read your blog. I was dx with MCD about 15mos ago. I am having trouble understanding the treatment process. When were you dx, and which medications have worked best for you? I was on high dose prednisone for a year. I was switched to Tacrolimus 4 mos ago. Recently my pharmacist changed my drug manufacturer from Prograf to a generic brand which I have not been able to locate on line. Do you know if the generic work as well as Prograf? How long were you in remission? Any treatment information that you can share will be greatly appreciated.