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Immunosuppression: Watching For and Managing Side Effects Sep 29, 2021 | By Kristin Eggebraaten (@keggebraaten)
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@stan1357

Hi,

What dose of tac are you taking? Also prednisone increases tac levels. My tac target is between 4 and 8 ng /no. I am currently at 8.7 trough and would like to reduce but docs don't want to. My dose is 1mg bd

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Replies to "Hi, What dose of tac are you taking? Also prednisone increases tac levels. My tac target..."
athenalee | @athenalee | Sep 18, 2021

Hello,

I am one year out of my liver transplant, I’ve had my Tacrolimus reduced from 4 mg am/pm, to 3 mg am/pm; my Mycophenolate from 2,000 mg am/pm to 1,000; I also take 300 mg Ursodial am/midday/pm (to help my new liver due to PBC which I still have); and, a multivitamin in the am. I had a very bad reaction to prednisone following my surgery, so I’ve not been on it since.

I take all my meds on an empty stomach at 8:15-8:30 am/pm. So far this works for me and I do not have any stomach issues. My trough is consistently 5.6-7. I’ve read that between 5-10 is optimal. I can send you a research paper I have on Tac trough levels if you’re interested.

Are you a liver transplant recipient? How many years? Are you liver functions ok. My AST and ALT are well within normal. My ALP remains high due to PBC, but even it has gone down which is good.

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