Whatever she needs for bone pain, is what she should take as long as it does not interfere with her quality of life. My husband has a bone marrow cancer that ate holes in all of his bones and collapsed 4 vertebrae. He has been on a low dose long acting oxy and it works pretty good, there is always some breakthrough pain but he lives with that over taking more opiates that would take away some quality of life. My brother with lung cancer has actually had very little pain, since the lungs don’t have pain receptors. It has not invaded his bones thankfully. I am hoping that your wife has enough control on the cancer to be able to reduce without pain. Are they managing the side effects from the immunotherapy?