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Neuropathy + Proton-pump Inhibitor use?? Anyone had this experience?
Neuropathy | Last Active: Apr 28 8:20pm | Replies (35)Comment receiving replies
Hello Amanda, thank you for your response. I have already read this paper and am not sure what to make of it! It seems like there is definitely a chance the two are connected but I have never spoke with anyone else who has made the connection. The PPI is the only medication I have been taking before the neuropathy flared up. I had some very similar symptoms in 2018–I stopped taking the PPI and they resolved. There is no way to really know for sure if they are related—but at this point I am really desperate to find a cause to the pain and nerve damage. Anyhow, thank you for your response Amanda!
Replies to "Hello Amanda, thank you for your response. I have already read this paper and am not..."
@piross1528 I have identical symptoms it seems while on omeprazole for 3-4 years for GERD. Have had peripheral neuropathy and even have been getting treated with IVIG. Wondering if it could be the omeprazole now. Are you better after stopping the PPIs? What exactly were your symptoms? I have had night sweats, facial itching, had and feet numbness and tingling, then even some imbalance and stumbling. Responds to IVIG but wondering if I just need to quit the PPI. Also had a recent bout of diarrhea coming and going for the last 6 weeks. Stopped the PPI and the diarrhea was better the next day.
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Very interesting question, and interesting (and technical) article Amanda shared. I have been on a PPI for ~10 years. I have had idiopathic PN for 6. I have moved and changed doctors 4 times in 20 years, and we never change anything assuming all from the past has been corrected by these meds. I have been on a goal to reduce my medicine list, especially for "fuzzy" things. My PPI is a med, along with one other prescribed 19 yrs ago, that I wonder if it ever was actually needed and if they can be stopped. It seems like my later doctors never want to take on questioning or changing what (now deceased) doctors did, and everything we do is just moving forward with new additions of drugs. Anyway, today I've decided I will stop taking my PPI (and I will send my PCP & GI a note since I don't see them for 6 months). What's the worst that can happen, I get acid reflux? If that happens, I can either re-start the PPI or try Pepcid for a while. If it does nothing to reduce my PN discomfort, at least I might find out after 10 years if I really have acid reflux!