Wow, that is a heavily debated question. Just so that you understand we are not doctors here. We are people just like you that are patients and caregivers. Some of us have done much research on our favorite topics, but our best information comes from personal experience. That being said I am going to attempt to unwrap some questions for you to help you get to the best answer for your wife. When your wife had the initial biopsy results of her DCIS, it would say if it showed hormone receptive or not. This could help guide this decision. If it is estrogen receptive the doctors would often recommend hormone therapy. This could be further driven by grade, with 1 being the least aggressive and 3 being the most aggressive. Sometimes doctors will order an onco dx score which is a recurrence prediction score, it isn’t perfect but it certainly is a useful tool. These are important decisions you are making and the more informed you are the better your decisions will be. These are all good questions to ask the oncologist. Do you have an oncologist that you trust and can ask questions? Did your wife have any other treatment in addition to the surgeries?