We are grateful for the "up"days . Everything was fine until last Friday when the pain hit---and it hit hard all at once. I am not sure that the Keytruda has had any effect on the nausea as it started before the treatment. I don't know that it has made it worse. He has always had a big appetite so it is difficult for him to just eat a few bites and be done. I have been able to get in extra calories along the way so that he has not lost weight. He has no option as to when he has the Keytruda---next time (2 1/2 weeks) it will be in the AM. We live in a 55+ community and this evening there was a "Taco truck" for a Labor Day celebration. He felt like walking down--about a block--the tacos were awful, but the point of the event is getting out of the house and seeing some neighbors. We stayed about 1 1/2 hours and he was ready to come home and went to bed exhausted. But, it was great to get him out of the house for a while.