I have major depression disorder reoccurring. I had surgery two months ago and was readmitted a week later with uncontrollable vomiting. They stopped all my medication because I couldn’t have anything by mouth. When I was released I decided to cut my Zoloft from 200mg to 150mg. I became nervous, agitated and depressed. I just didn’t want to talk to people or see them in person. I had forgotten that I reduced the medication. On my monthly visit to my psychiatrist after talking she said I have to look over your medication and change something you are not right. The more I talk with you I can see you are just not acting right. That’s when I remembered about the Zoloft and she told me to go home and immediately take the 50mg and up the dose back to 200mg. I do feel better. The point of this is yes this proves to me that I will have to remain on antidepressants the rest of my life.