Have you considered Chronic Faitigue Syndrome now called ME/CFS. The English discovered on various scans that the brain lining was involved. This, however, doesn't mean a cure exists. Since researchers seem to searching in their own particular directions. Also, have you been tested for Herpes Simplex One and Ebstein Barr Syndrome (mono?) Apparently, most of us walk around with titers to this. There are drugs that treat the Herpes group. They must be taken by mouth not rubbed on your mouth. Apparently, they don't always work. And, as has been said, a good rheumatologist is essential as an essential starting point. You might add a good neurologist,too. I must say I'm telling you all this and none of it has helped me. However, it's worth a try. Good luck. BiskitsMomma