Hello @ranchan, Welcome to Connect, an online community where patients and caregivers share their experiences, find support and exchange information with others. What a great question and one that a lot of us who have had neuropathy for awhile ask ourselves as we are praying for an "awakening" of peripheral nerves. Here's some information that I found that talks about it.

"What are the signs of nerve regeneration? -- The pain is a sign of irritation of the nerve; tingling is a sign of regeneration; or more precisely, tingling indicates the presence of young axons, in the process of growing." --- The Sign of "Tingling" in Lesions of the Peripheral Nerves: https://jamanetwork.com/journals/jamaneurology/article-abstract/570603

You might want to suggest to your sister to plan her conversation with the doctor at her upcoming appointment to ask the questions she would like to get answered. There is a great website that has some tips for planning the conversation for your next appointment that she might find helpful - https://www.patientrevolution.org/tools.

I've had idiopathic small fiber peripheral neuropathy for 20+ years and started taking supplements for it in 2016 and after a few months my numbness seemed to get a little better and the progression seems to have slowed or stopped but I haven't had any follow on nerve test to see if they are better that when I was diagnosed. Lately my feet feel a little more normal and I feel some tingling but not a lot. So I often think about that question - are my nerves starting to heal a little.

I also have carpal tunnel syndrome in my hands which sounds like it could be what your sister is experiencing also. Has she ever been tested for carpal tunnel syndrome?