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Kidney disease: Figuring out minimal change disease (MCD)

Kidney & Bladder | Last Active: Oct 16, 2021 | Replies (28)
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@rkndvm

Not sure about tacrolimus and insomnia. My never sleeping is related to the 50mg of pred I’m taking. I can sleep better on lower doses.

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rkndvm | @rkndvm | Sep 18, 2021

Just an update regarding my Nephrotic Syndrome MCD relapse. My early August urine Pr/Cr was 13.0. After being on 40 days of high dose prednisone, my urine Pr/Cr is almost normal (.276), so I will begin a slow taper… 5mg decrease pred every 2 weeks adding tacrolimus or mycophenolate as a second immunosuppressant when I am taking 20 mg pred daily. I am still trying to decide between the two drugs. I would very much appreciate any input regarding side effects of Prograf and CellCept. My rheumatologist prefers CellCept for lupus nephritis, but literature refers to the direct effect of tacrolimus on kidney podocytes (the actual cells allowing protein loss.)
Thanks to everyone contributing! I learn something with each person’s history.
RKN

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