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@becsbuddy

@renay110 i found some information for you. Yes, there are some drugs that you should avoid, but Prolia isn’t listed as one of them. Also, mast cell involvement with osteoporosis is very rare. These are some important questions that you want to ask your doctor!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526622/
https://emedicine.medscape.com/article/1057932-treatment
With the number of new medicines for osteoporosis, is there a reason your doctor wants you on prolia? Is there a way you can get a skin test by an allergist before taking prolia?

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Replies to "@renay110 i found some information for you. Yes, there are some drugs that you should avoid,..."

@renay110 I found another article for you. It seems to say that osteoporosis is more likely to happen in systemic mast disease than cutaneous mast disease. More likely to happen but still exceedingly rare.
https://link.springer.com/article/10.1007/s00198-019-04918-7
I hope the article is able to set your mind at ease. What type of MCD do you have?