i was on fosamax for 9 years and there wasn't that much improvement so rhematologist took me off it and started me give myself forteo shots every day for 2 years. Had a slight improvement. Didn't bother after my dr retired. Now another 10 years have passed and I am so bad another dr wants me to go on prolia shots. I am worried about it because it stays in system for 6 months and I have mast cell disease. Can't find anything on if it increases the histamine in the body. I am concerned because I get a couple hundred hives and have passed out from this disease when it gets activated. A skin biopsy found it was drug related from blood pressure pills. I had to switch at least 3 times before I found one that was ok. I found out that mast cells also cause osteoporosis.