@jwillits8 Looks to me like a good case for some autoimmune sleuthing. There are many good places to start, including http://www.omim.org, and http://www.hpo.jax.org, etc. Even better, and probably easier, are places like http://www.sequencing.com, http://www.ambry.com, Dante Labs.com. But first, make a list of all your symptoms and signs which you can use to sort through the info you will get. I have all the symptoms you mention, including wearing the Holter monitor and other medical equipment. I have ended up with a group of AI hits, including Myeloma>Amyloidosis>Gelsolin, Muscular Dystrophy (FKRP and FKTN with Walker Warburg), Cardiomyopathy, Encephalopathy, and a variety of cancers (Basal, melanoma, and others). Anyway, I believe you should think more in terms of "multiple" things gone wrong. OMIM.org and HPO.JAX. (human Phenotype Ontology) specialize in these cases. They are terrific help. oldkarl