@rkndvm, I am sorry that I do not remember the side effects when I began to take the Tacrolimus. I have been taking Tacrolimus and Mycophenolate since 2009 when I had my liver and kidney transplant. For 5-6 years I also took prednisone. My doses were high in the immediate post transplant period, but today I take 1.5 mg twice daily of the tacrolimus. I have routine blood labs to monitor the level of the tacrolimus in my blood.
The dose varies according to individual needs and is unique to the patient. I have been on 1.5 mg for a long time, my labs are currently every 3 months. Initially my labs were daily, weekly, biweekly, monthly and now 3 month intervals.
Tacrolimus must be taken at regular 12 hr intervals. Currently the noticeable side effects is occasional tremors. Any other effect has become part on my 'normal' living. Of course in my case, my transplant team does extra labs and checks for any unwanted effects during my annual evaluation.

I have had my 3rd Covid19 immunization. I an following the Mayo Clinic and the CDC guidance.

Are you currently taking Mycophenolate? Will you be adding Tacrolimus?

I’m Rosemary I am still researching the evidence for a 3rd vaccine. I take a flu shot ones a year because the flu virus mutates. I have lost several family members to Covid-19. One was a healthy 17yo football player. I am leaning towards taking a third shot