I am also on Plaquenil (Hydroxychloroquine) 200mgs twice a day. I have been on Prednisone since April of 2019 for PMR starting at 10 mgs. I have fluctuated back and forth several times to when I got down to 5 mgs. when I started to get pain again. I was put back to 8 mgs in June with the addition of the Plaquenil. I am now down to 2 mgs with no pain. However, I do feel fatigued and get short f breath easily. I did go for a Covid test which was negative. I am wondering if it's a combination of drugs (I am on Anestrozole after having breast cancer) or just the Plaquenil as I was not this fatigued before taking it. Does anyone else have problems with taking Plaquenil?