@stan1357 I'm glad to hear that they are clarifying that. The immunosuppressants that I have been on, first tacrolimus and now sirolimus, have just said "take with or without food" but have not made it clear that you need to be consistent. If you are not consistent it affects the amount of the drug in your system. When I realized this I mentioned to my transplant department that I would prefer to take it without food so I could drop the dosage. They followed me with extra lab work and I was able to drop from 4mg to 2.5mg by taking I without food.

I always figure the least amount of anything that you have to take, the better, but I suppose if less is being absorbed it's a moot point. It could make a big difference though for anyone who has to pay for their immunosuppressants. Mine are all covered by Medicare B.
JK