Help! Seems like the cancer has progressed after 3 rounds of immunotherapy - tumor in the liver is larger and there are 2 new ones (about 7 cm in size). Are three rounds usually sufficient? Or should we try to continue despite some bad side effects?

Some questions:

- Should we do,a liver biopsy to confirm that the cancer is melanoma?
- If the side effects are from the cancer and not the drugs, can we safely resume treatment? Side effects after last round were inability to sleep, urinary problems and overall fatigue. Also some feeling like in a fog - told it could be the higher ammonia level. The last round was only 1 of the 2 drugs thinking the yervoy caused the diarrhea/ GI issues. Only got opdivo for the third treatment.
- What other options are available for treatment? Based on the article below, it seems there are more tests that can be done and more options for treatment.

I cannot give up ... what should I do to help? Is sharing all the medical files with your melanoma team for an opinion something I can do? And do quickly since the melanoma seems so aggressive?

I’m willing to do anything including treatment with you even though we’re in the NY area.

Annie

Article I referenced:
https://surgery.ucsf.edu/conditions--procedures/liver-metastases.aspx