His latest MRI of 8/5/2021 shows progression of the cancer. There is one more chemo that we can try if he can avoid side effects. It's Irinotecan. The Oncologist doesn't seem very positive about its effectiveness. Otie is showing signs of memory and cognitive thinking issues. It breaks my heart. There doesn't seem to be anything that has a chance of working on a non-methylated glioblastoma. If anyone knows of anything, we are at the desperation stage.