John I have a question for you. I am having a bit of a problem. I have been taking my regular blood pressure medicine which is Benicar 20 mg every day. My cardiologist added Metoprolol 25mg XR ( 1/2 at bedtime) I have been doing this to keep my heart rate down. I started to notice my blood pressure is going up. It is staying in the 140-150's over 80-90. I have Clonidine 0.1 mg as needed. I have taken it last week and it worked. Now it is not. I spoke with my cardiologist and she wants me to up my Metoprolol to 25 mg at bedtime. I have read about gastrointestinal issues. It seems funny that all of a sudden my pills are not working. I took a clonidine last night. Clonidine usually works right away. This morning my heart rate is in the 60 range. When any other day it is in the high 70 range. I would take a metoprolol now except for that. I find it odd that all of a sudden my medications are not working. Is this common in people with neuropathy? This is very worrisome to me. If anyone else knows about this I would be glad to hear from them.