@kilh I have been back with Tymlos for 6 days now. The fluid retention was really the problem that I was quite sure was from Tymlos and it obviously was. That has not resumed yet, it took about three months for it to develop before. I suspect it will take less time this time.

Since my statin had caused extreme joint and muscle pain before my doctor reduced it from 20mg to 10mg I decided to take a week off from that to see if that might actually be my problem. I now think it is the major cause of those pains. I have gone two nights without taking it and my legs don't hurt nearly as much. I have learned that is a very common side effect of statins. I think the statin is the major cause and Tymlos made it a bit worse. If without the statin the amount of discomfort I have now is from Tymlos, it's very tolerable. I have read that if a patient has this problem with one statin that a change to a different one may not cause the same problem. I will speak to my doctor about it at the beginning of next week if things continue as they are. I felt comfortable stopping it for a week because when I had severe pain before he had me stop it for a week so I think a week off of it is not a huge problem. There are other drugs that I would never stop though without absolutely checking with my doctor in advance. In most cases I think that's a risky thing to do.

Are you taking any other drugs that could be contributing to the pain you have? I was amazed to discover that three drugs I take can all cause muscle and joint pain. I guess with those odds I was bound to have some pain. One of the drugs is essential though so I would not play around with that at all.
JK