I had rashes on my legs, water retention, swelling and severe pain with Prolia and was switched to Tymlos. With it I had all the other side effects on Tymlos but the worst one was when after having blood labs done, my results were in the critical levels so was sent to drive myself to two emergency rooms where I was immediately hospitalized at the second one for hypercalcemia. I had to stay overnight and was hooked up to an I.V. to flush out the excess calcium. Two months later I was given an infusion of Reclast which also had severe side effects and for up to two years later, I couldn't have any other osteoporosis meds. At five months after the hypercalcemia event, my neurosurgeon told me that my heart could have stopped and I could have died with the critical levels caused by the Tymlos.