Thanks for your reply John. My rheumatologist has said a few times that I may end up using them in the future. I’m a very positive person and was thinking that I will find remission through the the normal treatments. After 14 months, recently tapering off and immediately having the pain return, I am back on 5 mg. of Prednisone. As I taper to 4 it’s getting bad again. So, I’m thinking it’s time for a serious discussion about the possible success of biologics and discussing the downside. I hope someone else has tried this and can add some personal insight.