My husband has been on Linzess for about two months but so far we have not had good results. He has a history of constipation, but he also has moderate kidney disease so some things he cannot take. He also has to take iron supplements which work against him. Since he has been on the Linzess, he goes days with no bowel movement then suddenly has explosive diarrhea. As he says, he is then wiped out for hours. He takes the Linzess according to directions—30 minutes before breakfast—then has to stay home until it hits. I am wondering if a probiotic would work better. Also I don’t think he gets enough fiber or exercise, but I try not to make too many suggestions. He is on 145 mg of Linzess. Started on 72mg over a month ago and moved up when it didn’t help. I would have to say that he has not been helped by Linzess. Going to see what the doctor says next. He is only going to kidney doctor and primary care now. He had a colonoscopy two years ago and things were ok, but may be time to see him again. Any suggestions welcome.

Linzess never worked for me,