when I first was diagnosed with neuropathy blood tests showed that I had a very high level of B6 (246) in my system. After I quit taking all supplements that content B6 my level came down to 35 however my non-diabetic neuropathy is getting worse. My Neurologist told me a year ago that it would take about 6 month to show some improvement. Just the opposite. I am watching my diet and drink lots of water. My lower legs are numb and pain full and swollen around the ankle. Makes i hard to sleep.