I find this discussion very interesting. I had a partial knee replacement about eight years ago that didn't help reduce my knee pain, so I had a total replacement in October, 2016. About three days later, my liver failed and then I went into multi-organ failure. Long story short, I was life-flighted to SLC for a transplant with only hours left to live. The transplant team couldn't find a reason for the liver failure but said it had to have been a drug interaction from the TKR. I've had many other surgeries with no issues. I've wondered if it could have been caused by the bone cement or the metal of the implant.