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DiscussionTips on minimizing withdrawal symptoms from Effexor (aka Venlafaxine)
Depression & Anxiety | Last Active: 5 days ago | Replies (6363)Comment receiving replies
Replies to "Do you think I could reinstate after 5 weeks off and a failed prozac bridge? I'm..."
Yeah, I think your taper was too fast. Like you, I was on Effexor (venlafaxine) for a long time—18 years. I warn you, Effexor gets stored in fatty tissue all over your body I was only ever on 25 mg Effexor/venlafaxine (for hot flashes caused by breast cancer treatment); I didn't develop withdrawal symptoms until 6.5 weeks AFTER I slowly tapered off. I think it took those weeks for all my body stores to be used up.
I don't know if reinstating would help you, or not. You could try it for a couple of days and see. In my case, I went into the whole process of getting off Effexor without realizing how difficult it would be—my oncologist just said to cut my pills, take a quarter less for a couple of weeks and cut again by a quarter until I was off. I had what was left of a six-month supply and no prescription refill. I didn't know I was in trouble until 6.5 weeks after my last dose. I started researching Effexor withdrawal BECAUSE I was experiencing it. Once I read others' stories, I didn't think my reinstating after so long would do any good. What did help was to take a number of OTC supplements—GABA (a brain neurotransmitter) and ESPECIALLY, L-tryptophan, an amino acid which the body changes into serotonin. (NOTE to others reading this post who are still on Effexor—Do NOT take L-tryptophan, or 5-HTP while still on Effexor as this can trigger serotonin syndrome.) You can click on my name and go to Discussions to read my previous posts and see how much/how often I took the various supplements.
I'm sorry the Prozac "bridge" didn't work for you. Did your doctor cross-titrate between the two antidepressants (have you go down on the Effexor and go up on the Prozac), or did he just have you switch over to Prozac?—
(https://www.depressionforums.org/forums/topic/107532-coming-off-of-effexor-with-prozac-bridge/)
A commenter to the above forum wrote, "If you have issues with anxiety/irritability/etc., then you can take a benzo temporarily, like Xanax, Ativan (short-acting), Klonopin, Valium (long-acting), etc."
I can attest to the effectiveness of Valium for those issues. As well as my daily regimen of OTC supplements, my oncologist prescribed 5 mg Valium/diazepam to take as needed when my akathisia and/or anxiety got too bad. (I took those Valium sparingly, seldom more than a 1/2 tablet for a day, or two, as the prescription was for a small quantity of pills.) A couple of months later, I ended up going to Care Now after a particularly stressful Friday at work because my agitation was through the roof. The doctor I saw was familiar (very unusual!) with Effexor withdrawal. She had me stay home for three days and gave me prescriptions for l-methylfolate (an easily metabolized version of Vitamin B) and Valium. I was to take a whole Valium twice a day and rest. Her thinking was that I needed to use a significant amount of Valium to stabilize (she described it as "getting ahead of the anxiety") and then back off the drug.
Hope this helps.
Yes 6.5 months was way too fast. I tapered Paxil over a nine month period. Was doing great for months then all hell broke loose and I wound up in the hospital. Effexor and Paxil are probably the two hardest to taper. You have to go extremely slow. Most doctors are totally clueless in regards to tapering. I still don’t understand why the doctors and pharmacists think these drugs are great and hand them out like candy. Every bit as bad as bad as a benzo in my opinion.