I had problems sleeping on the 40 - 25 mg. dosage of prednisone I was on. The doctor prescribed an anti-depressant at a low dose - Trazodone 50 mg - when needed for sleeping. It was okay, but I still woke up after sleeping a couple of hours and had difficulty getting back to sleep. I ordered slow dose melatonin, then read the warnings, "Do not take this product if you have an autoimmune disorder" so that was a no go. What's been working for me are organic herbal teas - sleepy time or nighty night kind of teas. I wake up after a couple of hours, but can get back to sleep for a couple more hours. I just checked and couldn't find any interactions between prednisone, valerian and lemon balm, but you may want to do your own search or check with your pharmacist.