Hi @floridabonnie, Prednisone at a lower dosage relieves the symptoms of PMR. If it doesn't, you could have Giant Cell Arteritis, which requires a higher dosage of prednisone. The test for that is a biopsy of the temporal artery. Have you let your doctor know what is going on? Do you have any scalp tenderness, pains in the head, or trouble with your eyes? If you do, don't delay in letting your doctor know. Before prednisone, I had no appetite, extreme fatigue, horrible neck pain, scalp tenderness, and anemia. If your symptoms don't respond to Prednisone, it could be something else - an infection, malignancy or connective tissue disorder (this from a medical textbook). I hope that helps @floridabonnie Prednisone at a lower dosage relieves the symptoms of PMR. If it doesn't, you could have Giant Cell Arteritis, which requires a higher dosage of prednisone. The test for that is a biopsy of the temporal artery. Have you let your doctor know what is going on? Do you have any scalp tenderness, pains in the head, or trouble with your eyes? If you do, don't delay in letting your doctor know. Before prednisone, I had no appetite, extreme fatigue, horrible neck pain, scalp tenderness, and anemia. If your symptoms don't respond to Prednisone, it could be something else - an infection, malignancy or connective tissue disorder (this from a medical textbook). I hope that helps.