How bad is your fatigue? Several of us here have very mild bronchiectasis/MAC, and have never done the 3-antibiotic treatment. Our “treatment” consists of nebulizing 7% saline 1-2x/day and, for some, taking 600-1200 mg NAC/day (N-acetyl cysteine) and/or other supplements and/or using Aerobika or Acapella. (It’s been harder to get NAC recently. It had been an over the-counter supplement.) What eventually led to the diagnosis of bronchiectasis and MAC (after about 1 ½ yrs) was that I coughed up about 2-3 TBS blood while lap swimming in 2017. The blood scared me, so I went to the ER, and they did a CT scan. My only other symptom is that I cough up minor mucus/sputum in the mornings. I exercise/walk 2-3 miles daily (more slowly than I used to...).