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Positive ANA: What might be the cause?

Autoimmune Diseases | Last Active: Sep 26, 2023 | Replies (94)

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@georgiakate

Hi there,
Last year I had a positive ana of homogenous and mixed speckled pattern both with a titre of 1:1280. At the time I had a bunch of random symptoms including anemia, hair loss, dizziness, fatigue, fainting, headaches and nausea to name a few, I could barely stand up some days. I have had periods throughout the past 5 years where these symptoms come and go and had many tests but nothing ever eventuated until I had the positive Ana. I saw a rheumatologist who treated me with high dose steroids but my symptoms only 80% went away, he basically said that he doesn’t think it’s autoimmune related and to come back if I ever had symptoms again. My new GP retested my ANA which is now dense fine speckled pattern 1:2560. I am reading a lot of articles that DFS pattern can be clinically insignificant in “healthy individuals”. Can the other patterns go away or not show up if not currently in a ‘flare up’ or can they change? Just looking for some direction on where to go next with this information or weather I should be concerned. I have a few odd symptoms but I am not currently feeling as unwell as I have previously but have a few odd symptoms such as kidney/chest pain. any advice would be much appreciated. Thank you.

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Replies to "Hi there, Last year I had a positive ana of homogenous and mixed speckled pattern both..."

Hello @georgiakate Welcome To Mayo Clinic Connect. We are a group of individuals who help each other through health journeys by sharing information and tips and on what has worked for us and what has not. We are not medical professionals so we cannot diagnose or prescribe medication, we can simply prescribe information, resources and tips.
You have seen a rheumatologist who detected a high ANA score but he he does not think that there you have an auto immune disease. You do have lots of vague problems or symptoms but he doesn’t think these are important. Is that correct? Then your GP finds that your ANA score almost doubled.
Can you return to the rheumatologist, tell him that your ANA has doubled, and ask about special lab work for autoimmune diseases?

https://hoagmedicalgroup.com/articles/what-does-a-positive-antinuclear-antibody-mean/. I added this link about some rheumatologists talking about autoimmune diseases.

Will you come back and let me know what you have learned? Becky

@georgiakate, I add my welcome to Becky's. You'll notice that I moved your message to this existing discussion on the same topic. I encourage you review the past posts and connect with members. You may also be interested in this older discussion with great info and support:
- What can cause ANA titre of 1:2560? https://connect.mayoclinic.org/discussion/what-can-cause-ana-titre-of-12560/