I just started Methatrexate last week. Today was my second time taking it. I have not had any side affects at all. The reason I decided to take it, 10 MG once a week, is because I could only get down to 8 MG of prednisone for a few days before a major flare up. The steroids are far worst than the methatrexate according to all the research I have done. It is scary when you read all the "possible" side affects for sure...they have to include them with any drug and most all have scary side affects. I will you well, and I will let you know how I make out on this plan. I should say that I have been on steroids for almost a year.